In-game, the Prime Laser Rifle can be visually distinguished from the Laser Rifle by its golden yellow projectiles while firing, as opposed to the latter's blue projectiles.
The Prime Laser Rifle features improved base damage, rate of fire, status chance, critical chance, and critical damage over the standard Laser Rifle.
The Prime Laser Rifle is the first Primed Sentinel weapon, and the first Primed item to have the term "Prime" as prefix rather than a suffix.
Despite the weapon itself being based off the Laser Rifle, the Prime Laser Rifle's icon is a primed version of the Burst Laser.
When the Wyrm Prime was first introduced, it came equipped with the standard Laser Rifle on PC version, but it came equipped with the Prime Laser Rifle on the PS4. This technically makes the Prime Laser Rifle the first piece of content to appear on consoles first before the PC. This discrepancy was fixed in Actualización 13.9.2.